SATB2-associated syndrome (SAS) is caused by changes in the SATB2 gene. This gene is on chromosome 2 at position q33.1 and makes a protein called SATB2. The SATB2 protein works as a transcription factor for some other genes. The SATB2 protein has important roles in how organs and systems in the human body develop.

Summary of SATB2 (FLJ21474, KIAA1034) expression in human tissue. Selective nuclear expression in large intestine and subsets of neuronal cells in brain.

The title must be short and there should be no summary, keywords or subheadings. 2018-04-28 · varicose vein histology pathology outlines Posted on April 28, 2018 by cludmoch86mler Many vegetables have more sugar than people realize, making them suitable for dessert, whether it’s at a top restaurant or on your home table. Apr 13, 2018 6. Pathology is an effective method of investigating in CUP. SATB2: involved in regulation of transcription.

Satb2 pathology outlines

* IHC. neuroendocrine tumors The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using … SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. 2020-06-07 SATB2 was then identified as a potential immunohistochemical marker of human colorectal epithelium through screening of the Human Protein Atlas database by Magnusson et al. 3 The authors characterized the expression profile of SATB2 in normal human tissues using tissue microarrays, and found it to be highly expressed in the epithelium of the lower gastrointestinal tract (including appendix, colon, and … Our results indicate that SATB2 is a highly sensitive marker (100% sensitivity) for metastatic MKT-AdexGCCs with high specificity (100% specificity when showing strong staining in at least 75% cells) among MKTs. SATB2 is a useful marker for determining the primary sites of MKTs of the ovary. Summary of SATB2 (FLJ21474, KIAA1034) expression in human tissue.

SATB2 and CK20 positivity in normal colon, adenomas, primary CRC stage I, II, and III/IV, and metastatic CRCs. Bar diagram showing the percentage of positive cases from normal, adenomatous, and

Our results indicate that SATB2 is a highly sensitive marker (100% sensitivity) for metastatic MKT-AdexGCCs with high specificity (100% specificity when showing strong staining in at least 75% cells) among MKTs. SATB2 is a useful marker for determining the primary sites of MKTs of the ovary. 2019-11-26 · SATB2 (special AT-rich sequence binding protein 2) is a recently described transcription factor which is both sensitive and specific to colorectal epithelium [13, 14]. SATB2 has been proven to be negative in POMNs with the exception of cases arising from teratoma, making it a superior marker in comparison to CK20 and CDX2 [15,16,17].

The SATB2-associated syndrome (SAS) was proposed recently, after the SATB2 gene was initially discovered to be associated with isolated cleft palate. This syndrome is characterized by intellectual disability with delayed speech development, facial dysmorphism, cleft or high-arched palate, and dentit …

We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features. SATB2: MIM i: 119540, phenotype: OpenTargets i: ENSG00000119042: Orphanet i: 251019, 2q32q33 microdeletion syndrome 251028, SATB2-associated syndrome due to a chromosomal rearrangement 576283, SATB2-associated syndrome due to a pathogenic As the need for a more colorectal-specific marker has emerged, special AT-rich sequence-binding protein 2 (SATB2) has been used with success and promise.

Web: mayocliniclabs.com: Email: mcl@mayo.edu: Telephone: 800-533-1710: International: +1 855-379-3115: Values are valid only on day of printing. SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator (Dobreva et al., 2006, Dobreva et al., 2003). The effects of SATB2 expression on prognosis and metastasis are different in CRC than any other cancer type. SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. SATB2 and CK20 positivity in normal colon, adenomas, primary CRC stage I, II, and III/IV, and metastatic CRCs.
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SATB2 is part of the family of matrix SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.
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However, its expression is affected by molecular alterations. Inflammatory bowel disease–associated neoplasia demonstrates molecular alterations that are different from those in sporadic colorectal 2018-02-01 Special AT-rich sequence-binding protein 2 also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling.

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The SATB2 protein has important roles in how organs and systems in the human body develop. 2017-01-24 The designation of SATB2 ‐associated syndrome (SAS) was recently proposed by Docker et al. [ 2014] as a new clinically recognizable syndrome that should be considered in patients with ID and absent or severely impaired speech, cleft or highly arched palate, dental abnormalities, and skeletal anomalies. The SATB2-associated syndrome (SAS) was proposed recently, after the SATB2 gene was initially discovered to be associated with isolated cleft palate.